Isakhel Tehsil is an administrative subdivision (tehsil) of Mianwali District in the Punjab province of Pakistan. The city of Isakhel is the headquarters of the tehsil which is administratively subdivided into 14 Union Councils. It is located between 32° 30′ and 33° 14′ N. and 71° 7′ and 71° 44′ E., with an area of 678 square miles (1,760 km2) and contains the towns of Isakhel, Kammar Mushani and Kalabagh
During British rule Isakhel became part of Mianwali District when the North-West Frontier Province was created in 1901.
According to the 1901 census, it contained the municipalities of Isa Khel (population, 7,630), the headquarters, and Kalabagh (5,824); and 43 villages. The land revenue and cesses in 1903-4 amounted to 1.6 lakhs. Lying on the west bank of the Indus, this tehsil is cut off from the rest of the District, and would seem to belong more properly to the North-West Frontier Province, but is separated even more completely from Bannu by the semicircular fringe of the Chichali and Maidani hills, which leave it open only on the river side. These hills drain into Isa Khel and make it fertile. Its extreme northern portion, known as the Bhangi Khel country, is a wild and rugged region, a continuation of the Khattak hills.
The tehsil derives its name from the Isa Khel tribe, a section of the Niazai Afghans, who, settling here during the sixteenth century, long maintained their independence of the Mughal empire, and at last succumbed to the Nawab of Dera Ismail Khan.[2
Isakhel is an important town located in the west of Mianwali District. It is a historical town named after Isa Khan, a famous Niazi chief. Until November 1901 Isa Khel was tehsil headquarters of Bannu District – however after the North-West Frontier Province was created from Punjab province, Bannu district was included in the NWFP without the Isakhel tehsil. Isa Khel became part of the newly formed Mianwali district of the Punjab.